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An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
8
Issue
5
Identifiers
DOI: 10.1371/journal.pone.0065043
Keywords
  • Research Article
  • Biology
  • Microbiology
  • Bacterial Pathogens
  • Gram Negative
  • Medical Microbiology
  • Microbial Evolution
  • Microbial Pathogens
  • Medicine
  • Infectious Diseases
  • Bacterial Diseases
  • Meningitis
  • Meningococcal Disease
  • Meningococcal Infections
  • Infectious Disease Control
  • Infectious Diseases Of The Nervous System
Disciplines
  • Biology

Abstract

Studies of meningococcal evolution and genetic population structure, including the long-term stability of non-random associations between variants of surface proteins, are essential for vaccine development. We analyzed the sequence variability of factor H-binding protein (fHbp), Neisserial Heparin-Binding Antigen (NHBA) and Neisseria adhesin A (NadA), three major antigens in the multicomponent meningococcal serogroup B vaccine 4CMenB. A panel of invasive isolates collected in the Netherlands over a period of 50 years was used. To our knowledge, this strain collection covers the longest time period of any collection available worldwide. Long-term persistence of several antigen sub/variants and of non-overlapping antigen sub/variant combinations was observed. Our data suggest that certain antigen sub/variants including those used in 4CMenB are conserved over time and promoted by selection.

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