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Levels of cyclic AMP in murine L5178Y lymphoblasts grown in different concentrations of serum

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
55
Issue
3
Identifiers
DOI: 10.1016/0006-291x(73)91192-3

Abstract

Abstract Murine L5178Y lymphoblasts were grown in different concentrations of horse and fetal calf serum. Intracellular levels of cyclic AMP, determined throughout the growth period of these cells, did not vary significantly. Furthermore, logarithmically growing cells that became stationary did not show the pronounced increase in levels of cyclic AMP that is characteristic of other cell types when they become confluent or quiescent. These results demonstrate that the unrestricted growth of lymphoblasts is independent of the serum concentration used and may be due to an aberration in the cyclic AMP system.

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