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TheDrosophilatype II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFβ family signaling pathways

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
579
Issue
21
Identifiers
DOI: 10.1016/j.febslet.2005.06.088
Keywords
  • Transforming Growth Factor-β
  • Wishful Thinking
  • Bone Morphogenetic Protein
  • Activin
  • Myoglianin
  • Smad
  • Mad
  • Dsmad2
  • Medea
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Wishful thinking (Wit) is a Drosophila transforming growth factor-β (TGFβ) superfamily type II receptor most related to the mammalian bone morphogenetic protein (BMP) type II receptor, BMPRII. To better understand its function, we undertook a biochemical approach to establish the ligand binding repertoire and downstream signaling pathway. We observed that BMP4 and BMP7, bound to receptor complexes comprised of Wit and the type I receptor thickveins and saxophone to activate a BMP-like signaling pathway. Further we demonstrated that both myoglianin and its most closely related mammalian ligand, myostatin, interacted with a Wit and Baboon (Babo) type II–type I receptor complex to activate TGFβ/activin-like signaling pathways. These results thereby demonstrate that Wit binds multiple ligands to activate both BMP and TGFβ-like signaling pathways. Given that myoglianin is expressed in muscle and glial-derived cells, these results also suggest that Wit may mediate myoglianin-dependent signals in the nervous system.

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