Affordable Access

Publisher Website

A simple method for desymmetrizing 1,1′-ferrocenedicarboxaldehyde

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.tetlet.2014.05.040
Keywords
  • Ferrocene
  • Oxidation
  • Desymmetrization
  • Carboxylic Acid
  • Michael Addition

Abstract

Abstract A simple chromatography-free method for desymmetrizing ferrocene is described starting from the readily available dialdehyde. Oxidation of 1,1′-ferrocenedicarboxaldehyde in a water/acetonitrile mixture with KMnO4 produced 1′-formyl-ferrocenecarboxylic acid. The same reaction carried out in a water/acetone mixture produced 1′-[(E)-3-oxo-but-1-enyl]-ferrocenecarboxylic acid.

There are no comments yet on this publication. Be the first to share your thoughts.