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Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
222
Issue
2
Identifiers
DOI: 10.1016/j.canlet.2004.09.016
Keywords
  • Peroxisome Proliferator-Activated Receptor-α (Pparα)
  • C-Myc
  • Human Hepatoma Cells
  • Rat Hepatoma Cells
  • Proliferation
  • Apoptosis

Abstract

Abstract Humans appear to be refractory to some effects of peroxisome proliferators including alterations in cell proliferation, whereas rodents are susceptible. In this study, differences between the human and rat response to peroxisome proliferators were evaluated using rat and human tumour liver cell lines. Rat 7777 cells were more responsive than human HepG2 cells to ciprofibrate as they exhibited a higher decrease in cell number than HepG2, and underwent apoptosis. Results from these studies reveal a surprising response in tumour cell lines as the typical in vivo response of increased cell proliferation and reduced apoptosis was not observed in rat tumour cell lines at concentrations greater than those used to elicit the former response.

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