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O-Methoxycarbonyl Cyanohydrin as a New Protective Group for Carbonyls

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
56
Issue
33
Identifiers
DOI: 10.1016/s0040-4020(00)00535-4
Keywords
  • Protecting Groups
  • Aldehydes
  • Ketones
  • Cyanohydrins
  • Carbonates
Disciplines
  • Chemistry

Abstract

Abstract O-Methoxycarbonyl cyanohydrin, a new protective group of carbonyls, was prepared in high yields by an efficient one-step procedure using methyl cyanoformate and a secondary alkylamine at room temperature. Herein, we report efficient methods for the formation and cleavage of the protective group. Also, the ability of different types of carbonyls to be protected and the protective group's behavior under different chemical conditions were studied.

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