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Anthropometric factors and ovarian cancer risk in the Malmö Diet and Cancer Study

Authors
Journal
Cancer Epidemiology
1877-7821
Publisher
Elsevier
Volume
35
Issue
5
Identifiers
DOI: 10.1016/j.canep.2011.01.003
Keywords
  • Anthropometry
  • Ovarian Cancer Risk
  • Histological Subtype
  • Differentiation Grade
  • Clinical Stage

Abstract

Abstract Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36–1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09–0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10–0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.

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