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A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2

Informa Healthcare
Publication Date
  • 111500 Pharmacology And Pharmaceutical Sciences
  • Cortical Neurone Injury
  • Gw5074
  • Lrrk2 Mutants
  • Parkinson'S Disease
  • Medicine


7 VOLUME 37 : NUMBER 1 : FEBRUARY 2014 ARTICLE Full text free online at Thomas R Jarvis Clinical associate lecturer Workforce Education and Development Group Sydney Medical School1 Lewis Chan Staff specialist in Urology Concord Repatriation General Hospital Clinical associate professor (Surgery) Concord Clinical School1 Thomas Gottlieb Clinical associate professor Medicine (Immunology and Infectious Diseases) Concord Clinical School1 1 The University of Sydney Key words antibiotics, bacteriuria, catheters, cystitis Aust Prescr 2014;37:7–9 SUMMARY Lower urinary tract infections are common in the community and in hospitals. Management of acute uncomplicated infections in non-pregnant women is usually simple and involves antibiotic treatment for 3–5 days. Infections in men and recurrent, drug- resistant or complicated urinary tract infections require further evaluation. Confirming the cause is important to ensure the best treatment. Because of the risk of antibiotic resistance, asymptomatic bacteriuria should only be treated in select groups such as pregnant women and those undergoing an invasive genitourinary procedure. Bacteriuria in patients with a catheter should only be treated if they are symptomatic. While virulence factors play a role in the ability of a pathogen to cause an infection (such as pili which facilitate bacterial ascent), most important are the body’s natural defence mechanisms. These may be compromised in patients with diabetes, immunosuppression, urinary stone disease, some connective tissue diseases, hypo-oestrogenic states such as atrophic vaginitis in women, and bladder outlet obstruction from prostatic enlargement or stricture disease in men. Indwelling catheters are a common cause of bacterial colonisation and urinary tract infections. Presentation The presenting features of lower urinary tract infection include frequent urination or an urgent need to urinate, dysuria,

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