Affordable Access

Publisher Website

Serum cystatin C concentration as a marker of renal dysfunction in the elderly

Authors
Journal
American Journal of Kidney Diseases
0272-6386
Publisher
Elsevier
Volume
37
Issue
1
Identifiers
DOI: 10.1053/ajkd.2001.20628
Keywords
  • Cystatin C
  • Creatinine
  • Elderly
  • Glomerular Filtration Rate (Gfr)
  • Renal Function

Abstract

Serum cystatin C is a novel marker of renal function claimed to be superior to plasma creatinine. We assessed both parameters in young normotensive subjects (n = 12; 6 men; mean age, 25 ± 2 years) and elderly normotensive and hypertensive subjects (n = 41; 19 men; mean age, 67 ± 6 years). Glomerular filtration rate (GFR) was measured in all individuals using the inulin clearance (Cln) technique. Compared with young subjects, mean GFR was modestly but significantly (P<0.001) less in elderly subjects (young, 119 ± 11 mLmin/1.73 m2 versus elderly, 104 ± 12 mL/min/1.73 m2). Mean plasma creatinine concentration was identical in both groups (young, 0.93 ± 0.11 mg/dL versus elderly, 0.93 ± 0.10 mg/dL; P<0.90). Mean serum cystatin C concentration was significantly (P<0.001) greater in elderly subjects (0.84 ± 0.10 mg/L) compared with young subjects (0.69 ± 0.08 mg/L). In all but one elderly subject, plasma creatinine concentration was within the 95% confidence interval of plasma creatinine concentration in young subjects. Eleven of 41 elderly subjects (27%) had GFRs less than the lower 95% confidence interval, respectively, and 12 of 41 elderly subjects (29%) had a serum cystatin C concentration greater than the upper 95% confidence interval in young subjects. The correlation between serum cystatin C concentration and Cln (r = -0.65; P<0.001) was considerably better than between plasma creatinine concentration and Cln (r = -0.30; P<0.02). Serum cystatin C concentration is a better marker of renal dysfunction (ie, reduced GFR) than plasma creatinine concentration, at least in elderly subjects with plasma creatinine concentrations within the normal range.

There are no comments yet on this publication. Be the first to share your thoughts.