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Response to Comment on "Oscillations in NF-kappa B signaling control the dynamics of gene expression"

Authors
Journal
Science
0036-8075
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
Disciplines
  • Computer Science
  • Engineering

Abstract

Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

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