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DDT supports the growth of an estrogen-responsive tumor:Mammary tumor growth; pesticides

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
27
Identifiers
DOI: 10.1016/0378-4274(85)90127-4

Abstract

Abstract MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, form estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17β-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.

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