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Decreased E-Cadherin Expression in Endometrial Carcinoma Is Associated with Tumor Dedifferentiation and Deep Myometrial Invasion

Authors
Journal
Gynecologic Oncology
0090-8258
Publisher
Elsevier
Publication Date
Volume
53
Issue
2
Identifiers
DOI: 10.1006/gyno.1994.1113
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Decreased E-cadherin expression in tumor cells has been suggested to promote tumor invasiveness. We examined E-cadherin expression in 30 cases of endometrial carcinoma by immunohistochemistry using a monoclonal antibody to E-cadherin and investigated its correlation with other histopathologic features of the tumor. We observed that: (1) E-cadherin expression decreased with loss of differentiation ( P < 0.05); (2) E-cadherin expression was inversely correlated with depth of myometrial invasion ( P < 0.05); (3) decreased E-cadherin expression was correlated with paraaortic node metastasis ( P < 0.01); and (4) multivariate analysis comparing the depth of myometrial invasion to the pattern of E-cadherin expression, histologic grade, nuclear grade, and lymph-vascular space invasion showed that the depth of myometrial invasion was most strongly correlated with decreased E-cadherin expression ( P < 0.005). These findings seem to be consistent with the concept that the dissociation of cancer cells due to decreased expression of E-cadherin facilitates invasion of tumor cells.

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