Affordable Access

Publisher Website

Chronic ethanol imbibition interferes with δ-, but not with μ-opiate receptors

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
20
Issue
12
Identifiers
DOI: 10.1016/0028-3908(81)90070-8

Abstract

Abstract Treatment of rats with ethanol for 3 weeks resulted in a significant increase in δ-opiate receptor binding whereas no change in μ-opiate receptor binding was observed. Scatchard analysis showed an increase in δ-receptor affinity without a change in the receptor density. Acute treatment with ethanol did not alter receptor characteristics. The data provide evidence that δ- and μ-opiate receptor sites can be differentially modulated in vivo.

There are no comments yet on this publication. Be the first to share your thoughts.