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Methods for the isolation and characterization of constituents of natural products XIX. Use of a Celite-sodium borohydride column for reduction of carbonyl compounds at the micro level

Authors
Journal
Microchemical Journal
0026-265X
Publisher
Elsevier
Publication Date
Volume
20
Issue
1
Identifiers
DOI: 10.1016/0026-265x(75)90112-5

Abstract

Abstract A Celite-sodium borohyride column has been used to reduce micromole amounts of a variety of simple carbonyl compounds to the corresponding alcohol in fair to excellent yields. The procedure is relatively rapid and easy involving only the application of a hexane solution of the carbonyl compound to the column and collection of the effluent containing the alcohol. A column constructed in a melting point capillary suitable for the reduction of microgram amounts of carbonyls is also described.

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