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Inhibitory modulation of neuronal voltage-dependent sodium current by Phe-Met-Arg-Phe-amide

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
111
Issue
3
Identifiers
DOI: 10.1016/0304-3940(90)90283-f
Keywords
  • Sodium Current
  • Fmrfamide
  • Modulation
  • Neurotransmitter
  • Inhibition
  • Molluscan
  • Neuron
Disciplines
  • Biology

Abstract

Abstract The tetrodotoxin (TTX)-sensitive, voltage-gated Na +-current ( I Na) in a cluster of peptidergic neurons, involved in egg laying, in the CNS of the mollusc Lymnaea stagnalis, is modulated by the neuropeptide FMRFa (Phe-Met-Arg-Phe-NH 2). Application of FMRFa reversibly reduced the isolated I Na in a dose-dependent fashion. The physiological consequence is that the threshold for action potential generation is increased, causing an arrest of ongoing firing activity. The inhibitory action of FMRFa reported here is the first known example of modulation of the voltage-gated I Na by a putative neurotransmitter in intact nerve cells. This finding underlines the importance of modulation of ionic currents as a mechanism of regulation of neuronal excitability and includes the voltage dependent Na current in the range of currents subject to transmitter modulation.

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