Affordable Access

Publisher Website

Modification of the clozapine structure by parallel synthesis

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
16
Issue
17
Identifiers
DOI: 10.1016/j.bmcl.2006.06.034
Keywords
  • Dopamine Receptors
  • Clozapine
  • D1-Selective Antagonist
  • D2-Selective Antagonist
  • High-Throughput Synthesis
Disciplines
  • Design

Abstract

Abstract A structure–activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D 1-selective and D 2-selective compounds can be obtained.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Modification of the clozapine structure by paralle...

on Bioorganic & Medicinal Chemist... Sep 01, 2006

Effect of surface modification on parallel flow in...

on Chemical Engineering Journal Jan 15, 2013

Synthesis and structure analysis of kinematic stru...

on Mechanism and Machine Theory Jan 01, 2005

Approximate synthesis of planar Cartesian manipula...

on Mechanism and Machine Theory Jan 01, 2002
More articles like this..