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Modification of the clozapine structure by parallel synthesis

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
16
Issue
17
Identifiers
DOI: 10.1016/j.bmcl.2006.06.034
Keywords
  • Dopamine Receptors
  • Clozapine
  • D1-Selective Antagonist
  • D2-Selective Antagonist
  • High-Throughput Synthesis
Disciplines
  • Design

Abstract

Abstract A structure–activity study based on the core structure of clozapine 1b was accomplished by utilizing high-throughput synthesis. Several focused libraries were designed and synthesized to quickly develop SAR. The results indicate that by varying different regions of clozapine, both D 1-selective and D 2-selective compounds can be obtained.

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