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Drug sensitivity of pleomorphicTrypanosoma rhodesiense

Authors
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiene
0035-9203
Publisher
Oxford University Press
Publication Date
Volume
77
Issue
2
Identifiers
DOI: 10.1016/0035-9203(83)90066-4

Abstract

Abstract A fly-transmitted pleomorphic strain of Trypanosoma rhodesiense was found to be highly resistant to pentamidine, Ethidium and Antrycide, compared to a syringe-passaged monomorphic strain. Both strains were equally sensitive to pentavalent arsenicals and suramin. The results are discussed in terms of the possible occurrence of extravascular intracellular forms in the pleomorphic infection.

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