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Neonatal seizures with tonic clonic sequences and poor developmental outcome

Authors
Journal
Epilepsy Research
0920-1211
Publisher
Elsevier
Publication Date
Volume
65
Issue
3
Identifiers
DOI: 10.1016/j.eplepsyres.2005.05.009
Keywords
  • Newborn
  • Electro-Encephalography
  • Developmental Disabilities
  • Epilepsy
  • Vitamin B6
  • Kcnq2
  • Benign Familial Neonatal Convulsions

Abstract

Abstract Seizures consisting of a tonic followed by a clonic phase have rarely been described in neonates and are not included in the current classifications of neonatal seizures. Our video archive of 105 neonates with seizures or suspected seizures revealed six neonates with such tonic clonic or tonic myoclonic sequences. Two of those neonates had pyridoxine dependent seizures. The other four neonates had drug refractory seizures and demonstrated similarities in electro-clinical pattern, clinical course and outcome. Their seizures started with tonic posturing and after 10–20 s tonic posturing was superimposed by focal or multifocal cloni or myocloni. Ictal EEG started with voltage attenuation followed by bilateral or alternating focal epileptic discharges. The interictal EEG was abnormal. One child died, while the other three children became seizure free but had severe motor delay and mental retardation. In one of those three children, a de novo missense mutation was detected in the voltage gated potassium channel gene KCNQ2, indicating a genetic relationship between drug refractory neonatal seizures of unknown etiology with tonic clonic or myoclonic sequences and the well-known syndrome of benign familial neonatal convulsions (BFNC).

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