This investigation compared outcomes in disabled and non-disabled students taking courses by distance learning with the Open University UK in 2003. Students with mental health difficulties showed poorer course completion than non-disabled students. Students with restricted mobility and students with other disabilities showed lower pass rates than non-disabled students. Students with dyslexia or other specific learning difficulties showed lower pass rates and poorer grades than non-disabled students. Finally, students with multiple disabilities showed poorer course completion, lower pass rates and poorer grades than non-disabled students. Accommodations to support disabled students in distance education need to be focused on different groups of students with particular disabilities.