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d-Lysergic acid reduces microtubule-associated tau protein in SH-SY5Y human neuroblastoma cells

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
26
Issue
5
Identifiers
DOI: 10.1016/0306-3623(94)00272-o
Keywords
  • Tau Protein
  • Neuroblastoma
  • Lsd
Disciplines
  • Biology

Abstract

Abstract 1. 1. SH-SY5Y, an adrenergic human neuroblastoma cell line, was used to examine the hypothesis that d-lysergic acid (LSD) affects the metabolism of microtubule-associated tau protein, thus affecting microtubule assembly and the transport of neurotransmitters. 2. 2. After 48 hr treatment LSD (10 −5 and 10 −7 M) decreased 50 kDa tau protein in the membrane (pellet) fraction. The drug (10 −5 M) also decreased in the cytoplasmic (supernatant) fraction. 3. 3. This reduction in tau protein was accompanied by a 65% increase ( P < 0.05) in total protein after LSD (10 −7 M) in the cytoplasmic fraction.

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