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Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
1133
Identifiers
DOI: 10.1016/j.brainres.2006.11.072
Keywords
  • Biomarker
  • Oxidative Stress
  • 8-Ohdg
  • Parkinson'S Disease
  • Neurodegeneration
Disciplines
  • Medicine

Abstract

Abstract 8-Hydroxy-2′-deoxyguanosine (8-OHdG), the predominant marker of oxidative DNA damage, may be a good biomarker for monitoring the progression of Parkinson's disease (PD). Unfortunately, there are no basic laboratory data examining 8-OHdG levels in animal models of PD. In this study, we demonstrate that rats lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle display significantly elevated 8-OHdG levels in urine, serum, and substantia nigra, but not cerebrospinal fluid and striatum, compared to sham controls. These increments in 8-OHdG levels were detected at 2 days, but not at 7 days after the lesion suggesting that oxidative stress is restricted to the acute phase of 6-OHDA neurotoxicity. The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD.

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