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1,3-Oxazino[4,5-b]indole-2,4-(1H,9H)-diones and 5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-2,4-(1H,7H)-diones as serine protease inhibitors

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
4
Issue
7
Identifiers
DOI: 10.1016/s0960-894x(01)80270-5

Abstract

Abstract 9-Substituted-1,3-oxazino[4,5-b]indole-2,4-(1 H,9 H)-diones and 7-substituted-5,6-dimethylpyrrolo[2,3-d]-1,3-oxazin-2,4-(1 H,7 H)-diones are synthesized from indolo- or pyrrolo-β-enamino t-butyl esters in moderate yield. Certain compounds are found to inhibit human leukocyte elastase (HLE) and chymotrypsin selectively.

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