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Brain distribution of propranolol in the rat

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
55
Issue
3
Identifiers
DOI: 10.1016/0014-2999(79)90201-2
Keywords
  • Brain
  • Pharmacokinetics
  • D
  • L-Propranolol
  • Rat

Abstract

Abstract The distribution and kinetics of D,L-propranolol in rat brain were examined after an intravenous injection of the drug. Measurements in brain areas and blood were performed by means of a sensitive and specific gas liquid chromatographic method. The disappearance rate in cortical areas paralleled that in blood. However D,L-propranolol decreased at a slower rate in hypothalamic and medullary nuclei. Since propranolol is believed to have central hypotensive effects, its retention by certain central nuclei involved in blood pressure regulation is of interest.

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