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An automated method for preparation of [18F]sodium fluoride for injection, USP to address the technetium-99m isotope shortage

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
68
Issue
1
Identifiers
DOI: 10.1016/j.apradiso.2009.08.012
Keywords
  • [18F]Sodium Fluoride
  • Positron Emission Tomography
  • Isotope Shortage
Disciplines
  • Medicine

Abstract

Abstract The worldwide shortage of technetium-99m has created an immediate and urgent need for access to [ 18F]sodium fluoride for PET imaging of bone metastasis. In order to facilitate global availability of [ 18F]sodium fluoride for diagnostic nuclear medicine imaging procedures, a straightforward method for rapid production of [ 18F]sodium fluoride for injection, USP, using a modified GE Tracerlab FX-FN is presented.

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