Investigation of ultra trace detection in functionalised-surface enhanced Raman spectroscopy (SERS)

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Investigation of ultra trace detection in functionalised-surface enhanced Raman spectroscopy (SERS)

Authors
Keywords
  • Nanoparticles
  • 030000 Chemical Science
  • 100000 Technology
  • 030100 Analytical Chemistry
  • Surface Enhanced Raman Spectroscopy (Sers)
  • 030101 Analytical Spectrometry
  • 100700 Nanotechnology
  • 100708 Nanomaterials
  • Ultra Trace
  • Direct Detection

Abstract

We have developed an explanation for ultra trace detection found when using Au/Ag SERS nanoparticles linked to biochemical affinity tags, e.g. antibodies. The nanoparticle structure is not as usually assumed and the aggregated nanoparticles constitute hot spots that are indispensable for these very low levels of analyte detection, even more so when using a direct detection method.

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