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Experimental study of the internal signal of alliesthesia induced by sweet molecules in rats

Authors
Journal
Physiology & Behavior
0031-9384
Publisher
Elsevier
Publication Date
Volume
55
Issue
1
Identifiers
DOI: 10.1016/0031-9384(94)90026-4
Keywords
  • Alliesthesia
  • Palatability
  • Sweet Molecules
  • Consummatory Responses
  • Calorie
  • Nutrients
  • Rat

Abstract

Abstract To identify the preabsorptive signal that arouses alliesthesia, we compared the effects of five sweet molecules: glucose (3 g · 5 ml −1), cyclamate (0.280 g · 5 ml −1), saccharin (0.016 g · 5 ml −1), aspartame (0.020 g · 5 ml −1), and mannitol (3 g · 5 ml −1) on the ingestiveaversive responses of rats. In Experiment 1, the sweet stimuli were adjusted to taste similarly sweet, and they were administered orally; they aroused similar ingestive responses. In Experiment 2, an isovolumetric load of each of the five molecules was administered in the stomach and its influence on ingestive/aversive response aroused by oral sucrose was recorded. Negative alliesthesia was obtained after gastric loads of glucose and mannitol, but not after gastric loads of cyclamate, saccharin, and aspartame.

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