Affordable Access

Synthesis and selective anticancer activity of steroidal glycoconjugates

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Volume
54
Identifiers
DOI: 10.1016/j.ejmech.2012.06.027
Keywords
  • β-D-Glucosamine Steroidal Derivatives
  • Diosgenin
  • Hecogenin
  • Cervicouterine Cancer Cells
  • Antiproliferative Activity
  • Cytotoxicity
  • Selective Antitumor Activity

Abstract

Abstract The synthesis of glucosamine derivatives of the steroidal sapogenins diosgenin and hecogenin using the N-phthaloyl protected trichloroacetimidate of d-glucosamine as donor and TMSOTf as promoter is reported. The corresponding glycoconjugates were transformed into their acetamido derivatives and the hydrochloride salt (from diosgenin) and tested against HeLa, CaSki, and ViBo cervicouterine cancer cells. These compounds showed low cytotoxicity values on tumor cells and human lymphocytes, indicating that the main cell death process is presumably not necrosis. Significantly, the antiproliferative activity of these compounds on tumor cells did not affect the proliferative potential of peripheral blood lymphocytes.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Synthesis and anticancer cell potential of steroid...

on Bioorganic & Medicinal Chemist... Feb 15, 2015

Design, synthesis and biological activity of piper...

on European Journal of Medicinal... Jul 23, 2014
More articles like this..