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D2-symmetric dirhodium catalyst derived from a 1,2,2-triarylcyclopropanecarboxylate ligand: design, synthesis and application.

Authors
  • Qin, Changming
  • Boyarskikh, Vyacheslav
  • Hansen, Jørn H
  • Hardcastle, Kenneth I
  • Musaev, Djamaladdin G
  • Davies, Huw M L
Type
Published Article
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Publication Date
Nov 30, 2011
Volume
133
Issue
47
Pages
19198–19204
Identifiers
DOI: 10.1021/ja2074104
PMID: 22047062
Source
Medline
License
Unknown

Abstract

Dirhodium tetrakis-(R)-(1-(4-bromophenyl)-2,2-diphenylcyclopropanecarboxylate) (Rh(2)(R-BTPCP)(4)) was found to be an effective chiral catalyst for enantioselective reactions of aryl- and styryldiazoacetates. Highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and a combined C-H functionalization/Cope rearrangement were achieved using Rh(2)(R-BTPCP)(4) as catalyst. The advantages of Rh(2)(R-BTPCP)(4) include its ease of synthesis, its tolerance to the size of the ester group in the styryldiazoacetates, and its compatibility with dichloromethane as solvent. Computational studies suggest that the catalyst adopts a D(2)-symmetric arrangement, but when the carbenoid binds to the catalyst, two of the p-bromophenyl groups on the ligands rotate outward to make room for the carbenoid and the approach of the substrate to the carbenoid.

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