Affordable Access

Publisher Website

Synthesis and bronchodilator activity of new quinazolin derivative

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Publication Date
Volume
41
Issue
3
Identifiers
DOI: 10.1016/j.ejmech.2005.09.010
Keywords
  • Quinazolin
  • Bronchodilator
  • Vasicine
  • Guinea Pig Tracheal Chain
  • Theophylline
  • Salbutamol

Abstract

Abstract Taking lead from a naturally occurring quinazolin vasicine, a number of compounds were developed and evaluated for bronchodilator and anti-allergic activities. One of these compounds was 2,4-diethoxy-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-one, hereinafter named 95-4, exhibited marked bronchodilator activity evaluated on contracted trachea or constricted tracheo-bronchial tree. On intestinal smooth muscle too it showed relaxant effect. Tracheal relaxant effect was not found to be mediated through β-adrenoceptors. Cumulative dose–response study with acetylcholine and histamine indicated for its non-specific direct effect on smooth muscles. 95-4 was found to be more potent than theophylline and less to that of salbutamol on dose basis. Tested by a number of experimental models, it was found devoid of anti-allergic activity. It was also found to be free from any adverse effect. 95-4 due to its marked bronchial muscle relaxant effect can find use in conditions associated with spasm of bronchial muscles.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Synthesis and bronchodilator activity of new quina...

on European Journal of Medicinal... March 2006

Synthesis of new 2-thio-[1,2,4]triazolo[1,5-c]quin...

on CHEMICAL & PHARMACEUTICAL BULL... June 2009

Synthesis and anti-inflammatory activity of newer...

on European Journal of Medicinal... Jan 01, 2009

Synthesis and antimicrobial activity of some new q...

on Journal of Saudi Chemical Soci... Jan 01, 2011
More articles like this..