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Genetic network during neural crest induction: From cell specification to cell survival

Authors
Journal
Seminars in Cell and Developmental Biology
1084-9521
Publisher
Elsevier
Publication Date
Volume
16
Issue
6
Identifiers
DOI: 10.1016/j.semcdb.2005.06.001
Keywords
  • Neural Crest
  • Genetic Cascade
  • Cell Survival
  • Wnt
  • Fgf
  • Bmp
  • Retinoic Acid

Abstract

Abstract The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.

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