Affordable Access

Tekućinski antisolvent postupak taloženja za modifikaciju topljivosti bikalutamida

Croatian Pharmaceutical Society
Publication Date
  • Bikalutamid
  • Povećanje Topljivosti
  • OslobađAnje
  • Tekućinska Anti-Solvent Precipitacija
  • Bicalutamide
  • Solubility Enhancement
  • Dissolution Rate
  • Liquid Antisolvent Precipitation


Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E5 and Poloxamer 407 were shortlisted as a hydrophilic polymer and surfactant, respectively, for the process. Process optimization was done with respect to the hydrophilic polymer, surfactant and drug loading concentration. The resultant microcrystals were characterized with various instrumental techniques for material characterization such as IR, DSC, SEM, XRD, particle size, specific surface area and dissolution kinetics.

There are no comments yet on this publication. Be the first to share your thoughts.