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Spontaneous inhibitory postsynaptic potentials in guinea pig neocortex and olfactory cortex neurones

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
57
Issue
2
Identifiers
DOI: 10.1016/0304-3940(85)90051-5
Keywords
  • Neocortex Slices
  • Olfactory Cortex Slices
  • Inhibitory Postsynaptic Potential
  • γ-Aminobutyric Acid
  • Guinea Pig

Abstract

Abstract The membrane potential of olfactory cortex and neocortex neurones in vitro was recorded using conventional microelectrode techniques. During recordings with KCl- or CsCl-filled microelectrodes, spontaneous, subthreshold, transient membrane depolarizations were observed. These were abolished by the GABA A-receptor antagonist, bicuculline methiodide, and were prolonged by the barbiturate pentobarbitone. In most cells they were abolished by tetrodotoxin. It is concluded that these spontaneous depolarizations are inhibitory postsynaptic potentials arising from spontaneous activity in inhibitory interneurones.

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