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Single-dose cefminox versus triple-dose cefoxitin as antimicrobial prophylaxis in surgical treatment of patients with colorectal cancer

Authors
Journal
Current Therapeutic Research
0011-393X
Publisher
Elsevier
Publication Date
Volume
57
Issue
7
Identifiers
DOI: 10.1016/s0011-393x(96)80066-x
Disciplines
  • Medicine

Abstract

Abstract The efficacy of single-dose cefminox versus multiple-dose cefoxitin as antimicrobial prophylaxis in surgical treatment for colorectal cancer was compared in a prospective, randomized, single-masked, Phase III clinical trial. A total of 124 patients were entered into the study, and 31 were withdrawn after randomization. Of the 93 assessable patients, 47 received cefminox (2 g intravenously at induction of anesthesia) and 46 received cefoxitin (2 g intravenously at induction of anesthesia with subsequent doses 4 and 8 hours later). The incidence of postoperative infectious complications was similar in both groups: wound infection, 5 patients (10.6%) with cefminox and 3 (6.5%) with cefoxitin; intra-abdominal infection, 1 (2.1%) in the cefminox group and 1 (2.2%) in the cefoxitin group. Adverse events were few, and we found no statistical difference between antibiotic regimens. We concluded that single-dose cefminox 2-g monotherapy offers good prophylaxis in elective colorectal surgery. In this setting, cefminox is as effective as cefoxitin 6 g (2 g/4 h).

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