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10 Thrombopoietin and its receptor: structure, function and role in the regulation of platelet production

Authors
Journal
Baillière s Clinical Haematology
0950-3536
Publisher
Elsevier
Publication Date
Volume
11
Issue
2
Identifiers
DOI: 10.1016/s0950-3536(98)80058-9
Keywords
  • Thrombopoietin
  • Thrombopoietin Receptor
  • Haematopoiesis
  • Megakaryocytopoiesis
  • Platelet Homeostasis
  • Signal Transduction
Disciplines
  • Medicine

Abstract

Although thrombopoietin (Tpo) was already described in the early sixties, it took more than 30 years before it was cloned. It became possible after the recognition and cloning of its receptor, Mpl. In the past few years new information about Tpo and Mpl has accumulated rapidly. Structure, biosynthesis and tissue expression have been elucidated. The central role of Tpo in the regulation of megakaryocytopoiesis and platelet production has become clear, as has the way in which this is accomplished. Tpo appears to be an important growth factor for haematopoietic stem cells as well. Thus, it may become one of the most important factors in stem cell transplantation. Finally, the signal transduction mechanisms involved and the way in which Tpo affects platelets and their precursors functionally have been studied in detail. The cloning and characterization of thrombopoietin and its receptor Mpl is one of the most important advances in the haematology of the nineties.

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