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A radical approach toN-desulfonylation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
10
Identifiers
DOI: 10.1016/0040-4039(96)00086-x

Abstract

Abstract The deprotection of N-sulfonylated amides can be achieved under neutral conditions by reaction with tributylin hydride. Good yields are obtained using N-benzoyl and related amides while the corresponding N-acetyl derivatives are inert under the same reaction conditions. The mechanistic implications of this are discussed.

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