Affordable Access

Publisher Website

Glucocorticoid-remediable aldosteronism is associated with severe hypertension in early childhood

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Volume
138
Issue
5
Identifiers
DOI: 10.1067/mpd.2001.112648
Disciplines
  • Medicine

Abstract

Abstract Objectives: To review the childhood course of glucocorticoid-remediable aldosteronism (GRA) in order to provide management guidelines for hypertension in children. Methods: Records for 20 children with GRA (aged 1 month to 18 years; 16 with hypertension) were retrospectively reviewed. Results: Of the 16 children with GRA who developed hypertension, 50% had moderate-severe hypertension (blood pressure [BP] >99th centile for age and sex); 32% had mild hypertension (BP >95th and <99th centile), and 18% had borderline normal BP (BP >90th and <95th centile). Eight of 16 children with hypertension who received directed monotherapy (glucocorticoid suppression or aldosterone receptor/sodium epithelial channel antagonists) maintained BP below the 90th centile. Three additional subjects receiving a combination of directed therapies or a combination of directed therapies and nifedipine were unable to achieve BP control. At GRA diagnosis, 5 of 8 children were normokalemic, and plasma renin activity was suppressed in 5 of 5 subjects. Conclusions: Clinicians should have a high index of suspicion for GRA, especially in children with severe hypertension and a positive family history of early-onset hypertension and/or premature hemorrhagic stroke. Directed monotherapy is often successful in controlling BP in GRA. (J Pediatr 2001;138:715-20)

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Glucocorticoid-remediable aldosteronism is associa...

on The Journal of Pediatrics May 2001

Non-glucocorticoid-remediable aldosteronism in an...

on Pediatric nephrology (Berlin,... February 2004

[Glucocorticoid remediable aldosteronism].

on Nihon rinsho. Japanese journal... May 28, 2006

[Glucocorticoid-remediable aldosteronism (GRA)].

on Nihon rinsho. Japanese journal... February 2000
More articles like this..