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Enzyme (re)design: lessons from natural evolution and computation

Authors
Journal
Current Opinion in Chemical Biology
1367-5931
Publisher
Elsevier
Publication Date
Volume
13
Issue
1
Identifiers
DOI: 10.1016/j.cbpa.2009.01.014
Disciplines
  • Biology
  • Chemistry
  • Computer Science
  • Design

Abstract

The (re)design of enzymes to catalyze ‘new’ reactions is a topic of considerable practical and intellectual interest. Directed evolution (random mutagenesis followed by screening/selection) has been used widely to identify novel biocatalysts. However, ‘rational’ approaches using either natural divergent evolution or computational predictions based on chemical principles have been less successful. This review summarizes recent progress in evolution-based and computation-based (re)design.

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