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[D-Penacillamine. From constituent of penicillins to significant drug].

Authors
  • Lodemann, E
Type
Published Article
Journal
Die Naturwissenschaften
Publication Date
Sep 01, 1979
Volume
66
Issue
9
Pages
462–466
Identifiers
PMID: 503243
Source
Medline
License
Unknown

Abstract

D-Penicillamine is used against a variety of diseases. For many years it has been successful in treating Wilson's disease, cystinuria and heavy-metal poisonings. It also proved to be effective against rheumatoid arthritis, scleroderma, chronic active hepatitis, pulmonary fibrosis and multiple sclerosis. However, the use of D-penicillamine is still limited owing to the frequent occurrence of considerable, though generally reversible, side effects. This article deals with the history of D-penicillamine as well as the methods of its synthesis, its pharmacokinetics, effects and side effects. In addition, the significance of the stereo isomeric L-penicillamine is discussed.

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