Affordable Access

deepdyve-link
Publisher Website

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados.

Authors
  • Ngoc, Ninh Thi1, 2
  • Hanh, Tran Thi Hong1
  • Thanh, Nguyen Van1
  • Thao, Do Thi3
  • Cuong, Nguyen Xuan1, 2
  • Nam, Nguyen Hoai1, 2
  • Thung, Do Cong4
  • Kiem, Phan Van1
  • Minh, Chau Van1
  • 1 Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
  • 2 Graduate University of Science and Technology, VAST.
  • 3 Institute of Biotechnology, VAST.
  • 4 Institute of Marine Environment and Resources, VAST.
Type
Published Article
Journal
Chemical and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Publication Date
Jun 01, 2017
Volume
65
Issue
6
Pages
593–597
Identifiers
DOI: 10.1248/cpb.c17-00129
PMID: 28320975
Source
Medline
Keywords
License
Unknown

Abstract

Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50=21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50=28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50=20.53±2.26 µM) and SW480 (IC50=26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45±1.81 to 29.01±3.21 µM.

Report this publication

Statistics

Seen <100 times