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Cytotoxic germacrane-type sesquiterpenes, pimarane-type diterpenes, and a naphthalene derivative from Wollastonia biflora.

Authors
  • Chen, Wenliang
  • Tang, Weidong
  • Zhang, Rujun
  • Lou, Liguang
  • Zhao, Weimin
Type
Published Article
Journal
Journal of natural products
Publication Date
Apr 01, 2007
Volume
70
Issue
4
Pages
567–570
Identifiers
PMID: 17291042
Source
Medline
License
Unknown

Abstract

Phytochemical investigation of the whole plants of Wollastonia biflora led to the isolation and identification of three new germacrane-type sesquiterpenes (1-3), two new pimarane-type diterpenes (4, 5), and a new naphthalene glycoside (6), along with 11 known compounds. Their structures were characterized on the basis of spectroscopic analyses and chemical methods. Compounds 1, 2, and 3 showed significant cytotoxic activity against the growth of hepatocellular carcinoma BEL-7402 cells in vitro.

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