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Cytosolic BMAL1 moonlights as a translation factor.

Authors
  • Michael, Alicia K1
  • Asimgil, Hande1
  • Partch, Carrie L2
  • 1 Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA.
  • 2 Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. Electronic address: [email protected].
Type
Published Article
Journal
Trends in Biochemical Sciences
Publisher
Elsevier
Publication Date
Sep 01, 2015
Volume
40
Issue
9
Pages
489–490
Identifiers
DOI: 10.1016/j.tibs.2015.07.006
PMID: 26256246
Source
Medline
Language
English
License
Unknown

Abstract

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling. Copyright © 2015. Published by Elsevier Ltd.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 12/31/2019 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/26256246
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