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Cytoskeletal Requirements for Hepatitis C Virus (HCV) RNA Synthesis in the HCV Replicon Cell Culture System

Authors
  • Anne G. Bost
  • Daryl Venable
  • Lifei Liu
  • Beverly A. Heinz
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2003
Source
PMC
Keywords
License
Unknown

Abstract

Hepatitis C virus (HCV) induces microtubule aggregates in infected hepatocytes. To determine if cytoskeletal elements are important for HCV RNA synthesis, we examined the effect of cytoskeleton inhibitors on HCV replicon transcription in Huh7 cells. The data demonstrate that HCV replication complex-mediated RNA synthesis requires microtubule and actin polymerization.

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