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Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5'-O-α-Glucopyranoside, a Novel EGCG Derivative.

Authors
  • Han, Sang Yun1
  • Kim, Eunji2
  • Hwang, Kyeonghwan3
  • Ratan, Zubair Ahmed4
  • Hwang, Hyunsik5
  • Kim, Eun-Mi6
  • Kim, Doman7
  • Park, Junseong8
  • Cho, Jae Youl9
  • 1 Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea. [email protected] , (North Korea)
  • 2 Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea. [email protected] , (North Korea)
  • 3 Basic Research & Innovation Division, Amorepacific Corporation R&D Center, Yongin 17074, Korea. [email protected] , (North Korea)
  • 4 Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh. [email protected] , (Bangladesh)
  • 5 Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea. [email protected] , (North Korea)
  • 6 Basic Research & Innovation Division, Amorepacific Corporation R&D Center, Yongin 17074, Korea. [email protected] , (North Korea)
  • 7 Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea. [email protected] , (North Korea)
  • 8 Department of Engineering Chemistry, Chungbuk National University, Cheongju 28644, Korea. [email protected] , (North Korea)
  • 9 Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea. [email protected] , (North Korea)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
May 15, 2018
Volume
19
Issue
5
Identifiers
DOI: 10.3390/ijms19051466
PMID: 29762498
Source
Medline
Keywords
License
Unknown

Abstract

Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5'-O-α-glucopyranoside (EGCG-5'Glu), was synthesized, and its characteristics were investigated. EGCG-5'Glu showed antioxidant effects in cell and cell-free systems. Under SNP-derived radical exposure, EGCG-5'Glu decreased nitric oxide (NO) production, and recovered ROS-mediated cell viability. Moreover, EGCG-5'Glu regulated apoptotic pathways (caspases) and cell survival molecules (phosphoinositide 3-kinase (PI3K) and phosphoinositide-dependent kinase 1 (PDK1)). In another radical-induced condition, ultraviolet B (UVB) irradiation, EGCG-5'Glu protected cells from UVB and regulated the PI3K/PDK1/AKT pathway. Next, the proliferative effect of EGCG-5'Glu was examined. EGCG-5'Glu increased cell proliferation by modulating nuclear factor (NF)-κB activity. EGCG-5'Glu protects and repairs cells from external damage via its antioxidant effects. These results suggest that EGCG-5'Glu could be used as a cosmetics ingredient or dietary supplement.

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