Affordable Access

deepdyve-link
Publisher Website

Cytomegalovirus transmission in pediatric renal transplant recipients during the window period.

Authors
  • Gangopadhyay, Sanhita1
  • Rampersaud, Howard2
  • Pelletier, J Peter R3
  • Herman, Lettie1
  • Goldstein, Steven3
  • Upadhyay, Kiran1
  • 1 Division of Nephrology, Department of Pediatrics, Shands Children's Hospital, University of Florida, Gainesville, FL, USA.
  • 2 Shands Hospital Virology Laboratory, University of Florida Health, Gainesville, FL, USA.
  • 3 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Type
Published Article
Journal
Pediatric Transplantation
Publisher
Wiley (Blackwell Publishing)
Publication Date
February 2016
Volume
20
Issue
1
Pages
172–177
Identifiers
DOI: 10.1111/petr.12654
PMID: 26691349
Source
Medline
Keywords
License
Unknown

Abstract

We report two CMV naïve children who received deceased donor renal transplants from a CMV IgG-negative single donor. CMV IgG in both recipients and the donor were negative immediately prior to transplant. Both recipients had early recurrences of their original disease in their transplants, requiring multiple sessions of plasmapheresis. All blood products used were leukoreduced or CMV seronegative. A few days post-transplant, both recipients developed significant positive CMV viremia. Both required initiation of oral valganciclovir. Case 1 responded to oral valganciclovir only while the case 2 had a delayed response to it and hence required intravenous ganciclovir with good response. When checked retrospectively, CMV IgM in the donor was positive along with positive CMV DNA PCR from the white cells. Here we describe a very unusual scenario of CMV transmission in two pediatric renal transplant recipients from a single donor during the CMV window period.

Report this publication

Statistics

Seen <100 times