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Cytomegalovirus Retinitis in Patients With Acquired Immunodeficiency Syndrome After Initiating Antiretroviral Therapy.

Authors
  • Jabs, Douglas A1
  • Van Natta, Mark L2
  • Holland, Gary N3
  • Danis, Ronald4
  • 1 Departments of Ophthalmology and Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York; Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: [email protected]
  • 2 Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
  • 3 UCLA Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
  • 4 Department of Ophthalmology, The University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Type
Published Article
Journal
American journal of ophthalmology
Publication Date
February 2017
Volume
174
Pages
23–32
Identifiers
DOI: 10.1016/j.ajo.2016.10.011
PMID: 27984023
Source
Medline
License
Unknown

Abstract

Among persons with AIDS who experience immune recovery, there was neither an increased rate of new-onset CMV retinitis nor worsening of existing CMV retinitis in the first 6 months after initiating cART vs those without immune recovery. These data are consistent with the known 3- to 6-month lag in recovery of specific immunity to CMV after initiating cART and suggest that "immune recovery retinitis," a proposed immune recovery inflammatory syndrome phenomenon, is rare.

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