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[Cytokines in bone diseases. Bone anabolic action of PTH and role of cytokine].

Authors
  • Kaji, Hiroshi
  • Sugimoto, Toshitsugu
Type
Published Article
Journal
Clinical calcium
Publication Date
Oct 01, 2010
Volume
20
Issue
10
Pages
1555–1561
Identifiers
DOI: CliCa101015551561
PMID: 20890039
Source
Medline
License
Unknown

Abstract

Parathyroid hormone (PTH) has clinically appeared as a bone anabolic reagent in Japan. Local or systemic factors produced by various cells are involved in the bone anabolic action of PTH. Insulin-like growth factor-1 and fibroblast growth factor 2 are included in them. Although the significance of canonical Wnt signaling has been noted as bone anabolic signal, recent reports indicate that an activation of Wnt signaling through several proteins, such as Dkk1 and sclerostin, are related to the bone anabolic action of PTH.

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