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The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching

Authors
  • Xu, Junji1
  • Zanvit, Peter1
  • Hu, Lei2
  • Tseng, Pang-Yen3
  • Liu, Na1
  • Wang, Fu1, 4
  • Liu, Ousheng1, 5
  • Zhang, Dunfang1
  • Jin, Wenwen1
  • Guo, Nancy1
  • Han, Yichen1
  • Yin, Jessica1
  • Cain, Alexander1
  • Hoon, Mark A.3
  • Wang, Songlin2
  • Chen, WanJun1
  • 1 Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD 20892, USA
  • 2 Molecular Laboratory for Gene Therapy & Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China
  • 3 Molecular Genetics Section, Laboratory of Sensory Biology, NIDCR, NIH, Bethesda, MD 20892, USA
  • 4 Dalian Medical University, School of Stomatology, Dalian 114044, China
  • 5 Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha 410000, China
Type
Published Article
Journal
Immunity
Publication Date
Jul 15, 2020
Volume
53
Issue
2
Pages
371–383
Identifiers
DOI: 10.1016/j.immuni.2020.06.023
PMID: 32673566
PMCID: PMC7362873
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Xu et al. find that TGF-β, produced as part of the wound healing process, induces expression of interleukin-31 by dermal conventional type 2 DCs, which, in turn, increases neuron sensitivity and provokes itching.

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