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Cytokine profile of the rheumatoid nodule suggests that it is a Th1 granuloma.

Authors
  • Hessian, Paul A
  • Highton, John
  • Kean, Annabel
  • Sun, Cheuk Kwan
  • Chin, Michael
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Feb 01, 2003
Volume
48
Issue
2
Pages
334–338
Identifiers
PMID: 12571841
Source
Medline
License
Unknown

Abstract

The cytokine profile within the rheumatoid nodule (i.e., presence of IFNgamma but not IL-2, and prominent expression of IL-1beta and TNFalpha together with IL-12, IL-18, IL-15, and IL-10) is similar to the profile of cytokines in the synovial lesion of rheumatoid arthritis, which is generally accepted as being attributable to a Th1-mediated inflammatory mechanism. Our results suggest that damage to affected synovial membrane or subcutaneous tissue is caused by the same inflammatory mechanisms, and that the nodule is a Th1 granuloma.

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