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Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis.

Authors
  • Czaja, A J
  • Cookson, S
  • Constantini, P K
  • Clare, M
  • Underhill, J A
  • Donaldson, P T
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Sep 01, 1999
Volume
117
Issue
3
Pages
645–652
Identifiers
PMID: 10464141
Source
Medline
License
Unknown

Abstract

A polymorphism of the tumor necrosis factor gene occurs more commonly in patients with type 1 autoimmune hepatitis than in normal subjects; it is associated with a poorer response to corticosteroids. The polymorphism may be inherited as part of the extended A1-B8-DRB1*0301 haplotype and may affect both disease expression and behavior.

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