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Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis.

Authors
Type
Published Article
Journal
Gastroenterology
0016-5085
Publisher
Elsevier
Publication Date
Volume
117
Issue
3
Pages
645–652
Identifiers
PMID: 10464141
Source
Medline
License
Unknown

Abstract

A polymorphism of the tumor necrosis factor gene occurs more commonly in patients with type 1 autoimmune hepatitis than in normal subjects; it is associated with a poorer response to corticosteroids. The polymorphism may be inherited as part of the extended A1-B8-DRB1*0301 haplotype and may affect both disease expression and behavior.

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