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Influence of NleH effector expression, host genetics, and inflammation on Citrobacter rodentium colonization of mice

Authors
  • Feuerbacher, Leigh Ann
  • Hardwidge, Philip R.1, 2, 3
  • 1 Department of Diagnostic Medicine
  • 2 College of Veterinary Medicine
  • 3 Kansas State University
Type
Published Article
Journal
Microbes and Infection
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Feb 16, 2014
Identifiers
DOI: 10.1016/j.immuni.2014.01.003
Source
Elsevier
Keywords
License
Unknown

Abstract

The Escherichia coli NleH1 and NleH2 virulence proteins differentially regulate host transcription of innate immunity genes. The mouse pathogen Citrobacter rodentium encodes one NleH protein, which functions equivalently to E. coli NleH1. We examined the impact of host genetics and intestinal inflammation on the contribution of NleH to C. rodentium colonization of mice differing in LPS responsiveness. NleH expression was detrimental to C. rodentium in C57BL/10ScNJ mice, which do not mount LPS-induced inflammatory responses. This phenotype was reversed if inflammation was induced by chemical means. C. rodentium that expressed both E. coli NleH1 and NleH2 was hypervirulent in C3H/HeJ mice.

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